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Marine Biotechnology Department

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Tel: +39 0815833249
Skype: ipietro.tedesco

Curriculum Vitae




Research Interests

My research interests are mainly focused on the valorization of the biotechnological potential of marine microorganisms. One of the main goals is the identification of new molecules from marine microorganisms, which represent an untapped reservoir of compounds and enzymes with high potential especially for pharmaceutical, cosmeceutical and nutraceutical applications. This goal can be achieved by two different approaches. The first approach employs a biodiscovery pipeline starting from the isolation of  microorganisms from different marine environments. The extracts obtained from the cultivation of the isolated microorganisms are then purified by a bioassay-driven purification, using different screenings, to reach the identification of novel bioactive compounds. The second approach is instead genome-based. The genomes of bacteria of interest are sequenced and subjected to genome mining procedures to identify the biosynthetic clusters responsible for the synthesis of the molecules. The cluster are then cloned and recombinantly expressed in appropriate platform. The generation and optimization of these expression platforms is another of mine main research goals. Thanks to the constant technologic progress, the genome-based approach is becoming more appealing, but to unlock its full potential it is necessary to have appropriate and effective expression platforms for recombinant expression. Using metabolic engineering and exploiting the potential of metabolomics and fluxomics, I plan to create and optimize bacterial strains (chassis) for the recombinant expression of molecules of interest derived from marine microorganisms.

Selected Publications

Buonocore C, Tedesco P, Vitale GA, Esposito FP, Giugliano R, Monti MC, D'Auria MV, & de Pascale D. (2020). Characterization of a New Mixture of Mono-Rhamnolipids Produced by Pseudomonas gessardii Isolated from Edmonson Point (Antarctica). Marine drugs, 18(5), 269. https://doi.org/10.3390/md18050269

Parrilli E, Tedesco P, Fondi M, Tutino ML, Lo Giudice A, de Pascale D, Fani R. The art of adapting to extreme environments: The model system Pseudoalteromonas Phys Life Rev. 2019 Apr 4. pii: S1571-0645(19)30066-1. doi: 10.1016/j.plrev.2019.04.003.

Tortorella E, Tedesco P, Palma Esposito F, January GG, Fani R, Jaspars M, de Pascale D. Antibiotics from Deep-Sea Microorganisms: Current Discoveries and Perspectives. Mar Drugs. 2018 Sep 29;16(10). pii: E355. doi: 10.3390/md16100355.

Corral P, Esposito FP, Tedesco P, Falco A, Tortorella E, Tartaglione L, Festa C, D'Auria MV, Gnavi G, Varese GC, de Pascale D. Identification of a Sorbicillinoid-Producing Aspergillus Strain with Antimicrobial Activity Against Staphylococcus aureus: a New Polyextremophilic Marine Fungus from Barents Sea. Mar Biotechnol (NY). 2018 Apr 12. doi: 10.1007/s10126-018-9821-9.

Sannino F, Sansone C, Galasso C, Kildgaard S, Tedesco P, Fani R, Marino G, de Pascale D, Ianora A, Parrilli E, Larsen TO, Romano G, Tutino ML. Pseudoalteromonas haloplanktis TAC125 produces 4-hydroxybenzoic acid that induces pyroptosis in human A459 lung adenocarcinoma cells. Sci Rep. 2018 Jan 19;8(1):1190. doi: 10.1038/s41598-018-19536-2

Mangiagalli M, Bar-Dolev M, Tedesco P, Natalello A, Kaleda A, Brocca S, de Pascale D, Pucciarelli S, Miceli C, Bravslavsky I, Lotti M. Cryo-protective effect of an ice-binding protein derived from Antarctic bacteria. FEBS J. 2017 Jan;284(1):163-177. doi: 10.1111/febs.13965

Tedesco P, Maida I, Palma Esposito F, Tortorella E, Subko E, Ezeofor CC, Zhang Y, Tabudravu J, Jaspars M, Fani R, de Pascale D. Antimicrobial Activity of Monoramnholipids Produced by Bacterial Strains Isolated from the Ross Sea (Antarctica). Marine Drugs. 2016 Apr;14(5). DOI: 10.3390/md14050083.

Gnavi G, Palma Esposito F, Festa C, Polia A, Tedesco P , Fani R, Monti MC, de Pascale D, D'Auria MV, Varese GC. The antimicrobial potential of algicolous marine fungi to counteract multidrug resistant bacteria: phylogenetic diversity and chemical profiling. Res Microbiol. 2016 May 9.

Barone R, De Santi C, Palma Esposito F, Tedesco P, Galati F, Visone M, Di Scala A, de Pascale D. Marine metagenomics, a valuable tool for enzymes and bioactive compounds discovery. Front Mar Sci. September 2014 https://doi.org/10.3389/fmars

Izzo V, Tedesco P, Notomista E, Pagnotta E, Di Donato A, Trincone A, Tramice A. α-rhamnosidase activity in the marine isolate Novosphingobium sp. PP1Y and its use in the bioconversion of flavonoids.
Journal of Molecular Catalysis B: Enzymatic 105 (2014) 95–103

Book chapters
Haynes MK, Garcia M, Peters R, Waller A, Tedesco P, Ursu O, Bologa CG, Santos RG, Pinilla C, Wu TH, Lovchik JA, Oprea TI, Sklar LA, Tegos GP.High-Throughput Flow Cytometry Screening of Multidrug Efflux Systems. Methods Mol Biol. 2018;1700:293-318. doi: 10.1007/978-1-4939-7454-2_16.

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