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Research Infrastructures for marine biological resources (RIMAR) Department – BAC unit

e-mail: luca.ambrosino(at)szn.it
Tel. +39 081 5833452

Curriculum Vitae

Research Interests

I am a molecular biotechnologist with a PhD in Computational Biology and Bioinformatics gained at the University of Naples “Federico II”. I worked at CEINGE - Biotecnologie Avanzate S.c.a.r.l. on structural characterization of human disease-causing mutant enzymes; at the Institute of Protein Biochemistry (IBP) of CNR on the structural and functional characterization of extremophile enzymes with a biotechnological potential; at the Institute of Biosciences and Bioresources (IBBR) of CNR on functional and comparative genomics of species of agronomic interest; at the Agricultural Department of the University of Naples “Federico II” on comparative genomics and molecular evolution of plant species of agronomic interest; at Stazione Zoologica Anton Dohrn on structural and functional genomics, comparative genomics and molecular evolution, transcriptomics and structural proteomics of marine species.


I am member of the Bioinformatics, Computational Analysis & Data Management (BAC) unit of SZN. Within the unit, I am the contact person for genomics, transcriptomics and proteomics analyses. I mainly work on the development of bioinformatics tools and services for marine research in SZN.

Selected Publications

Pazzaglia, J., Santillán-Sarmiento, A., Ruocco, M., Dattolo, E., Ambrosino, L., Marín-Guirao, L., & Procaccini, G. (2022). Local environment modulates whole-transcriptome expression in the seagrass Posidonia oceanica under warming and nutrients excess. Environmental Pollution, 119077. DOI: 10.1016/j.envpol.2022.119077

Sabatino, V., Orefice, I., Marotta, P., Ambrosino, L., Chiusano, M. L., d’Ippolito, G., ... & Ferrante, M. I. (2022). Silencing of a Pseudo-nitzschia arenysensis lipoxygenase transcript leads to reduced oxylipin production and impaired growth. New Phytologist. DOI: https://doi.org/10.1111/nph.17739

Del Mondo, A., Smerilli, A., Ambrosino, L., Albini, A., Noonan, D. M., Sansone, C., & Brunet, C. (2021). Insights into phenolic compounds from microalgae: structural variety and complex beneficial activities from health to nutraceutics. Critical Reviews in Biotechnology, 41(2), 155-171. DOI: https://doi.org/10.1080/07388551.2021.1874284

Sañé, E., Del Mondo, A., Ambrosino, L., Smerilli, A., Sansone, C., & Brunet, C. (2021). The Recent Advanced in Microalgal Phytosterols: Bioactive Ingredients Along With Human-Health Driven Potential Applications. Food Reviews International, 1-20. DOI: https://doi.org/10.1080/87559129.2021.1938115

Esposito, A., Ambrosino, L., Piazza, S., D’Aniello, S., Chiusano, M.L., Locascio, A. (2021). Evolutionary Adaptation of the Thyroid Hormone Signaling Toolkit in Chordates. Cells 10(12), 3391. DOI: https://doi.org/10.3390/cells10123391

Marotta, P., Salatiello, F., Ambrosino, L., Berruto, F., Chiusano, M. L., & Locascio, A. (2021). The ascidia Ciona robusta provides novel insights on the evolution of the AP-1 transcriptional complex. Frontiers in Cell and Developmental Biology, 2093. DOI: https://doi.org/10.3389/fcell.2021.709696

Ruocco, M., Ambrosino, L., Jahnke, M., Chiusano, M. L., Barrote, I., Procaccini, G., Silva, J, and Dattolo, E. (2020). m6A RNA Methylation in Marine Plants: First Insights and Relevance for Biological Rhythms. International Journal of Molecular Sciences, 21(20), 7508. DOI: https://doi.org/10.3390/ijms21207508

Lauritano, C., Roncalli, V., Ambrosino, L., Cieslak, M. C., and Ianora, A. (2020). First De Novo Transcriptome of the Copepod Rhincalanus gigas from Antarctic Waters. Biology, 9(11), 410. DOI: https://doi.org/10.3390/biology9110410

Elagoz, Ali M., Ambrosino, L., and Lauritano, C. (2020) "De novo transcriptome of the diatom Cylindrotheca closterium identifies genes involved in the metabolism of anti-inflammatory compounds." Scientific reports 10.1: 1-9. DOI: https://doi.org/10.1038/s41598-020-61007-0

Ambrosino, L., Colantuono, C., Diretto, G., Fiore, A., and Chiusano, M. L. (2020). Bioinformatics Resources for Plant Abiotic Stress Responses: State of the Art and Opportunities in the Fast Evolving-Omics Era. Plants, 9(5), 591. DOI: https://doi.org/10.3390/plants9050591

Ambrosino, L.; Tangherlini, M.; Colantuono, C.; Esposito, A.; Sangiovanni, M., Miralto, M., Sansone, C., and Chiusano, M.L. (2019). “Bioinformatics for Marine Products: An Overview of Resources, Bottlenecks, and Perspectives.” Marine drugs 17, (10). DOI: 10.3390/md17100576

Esposito, A.; Tamburini, S.; Triboli, L.; Ambrosino, L.; Chiusano, M. L., and Jousson, O. (2019) “Insights into the genome structure of four acetogenic bacteria with specific reference to the Wood-Ljungdahl pathway.” MicrobiologyOpen 2019, e938. DOI: 10.1002/mbo3.938

Ambrosino, L., Vassalli, Q. A., D'Agostino, Y., Esposito, R., Cetrangolo, V., Caputi, L., Amoroso, A., Aniello, F., D'Aniello, S., Chatzigeorgiou, M., Chiusano, M.L., and Locascio, A. (2019). "Functional conserved non-coding elements among tunicates and chordates." Dev Biol 448(2): 101-110. DOI: 10.1016/j.ydbio.2018.12.012

Ambrosino, L., Ruggieri, V., Bostan H., Miralto, M., Vitulo, N., Zouine, M., Barone, A., Bouzayen, M., Frusciante, L., Pezzotti, M., Valle, G., Chiusano, M.L. (2018) “Multilevel comparative bioinformatics to investigate evolutionary relationships and specificities in gene annotations”, BMC Bioinformatics 19(15): 435. DOI: 10.1186/s12859-018-2420-y

Ambrosino, L., Colantuono, C., Monticolo, F., and Chiusano, M. L. (2018). “Bioinformatics resources for plant genomics: bottlenecks and opportunities in the -omics era.” in “Next-generation Sequencing and Bioinformatics for Plant Science” Current Issues in Molecular Biology 71-88 DOI: 10.21775/cimb.027.071

Ambrosino, L., Chiusano, M.L. (2017). “Transcriptologs: a transcriptome-based approach to predict orthology relationships.” Bioinformatics and Biology Insights 11 DOI: 10.1177/1177932217690136

De Santi, C., B. Altermark, M. M. Pierechod, L. Ambrosino, D. de Pascale and N. P. Willassen (2016). "Characterization of a cold-active and salt tolerant esterase identified by functional screening of Arctic metagenomic libraries." BMC Biochem 17(1): 1 DOI: 10.1186/s12858-016-0057-x

Ambrosino, L., Bostan, H., Ruggieri, V., and Chiusano, M. L. (2016). “Bioinformatics resources for pollen.” Plant reproduction 29 (1-2), 133-147 DOI: 10.1007/s00497-016-0284-8

Ambrosino, L., H. Bostan, P. di Salle, M. Sangiovanni, A. Vigilante and M. L. Chiusano (2016). "pATsi: Paralogs and Singleton Genes from Arabidopsis thaliana." Evol Bioinform Online 12: 1-7 DOI: 10.4137/EBO.S32536

De Santi, C., L. Ambrosino, P. Tedesco, L. Zhai, C. Zhou, Y. Xue, Y. Ma and D. de Pascale (2015). "Identification and characterization of a novel salt-tolerant esterase from a Tibetan glacier metagenomic library." Biotechnol Prog 31(4): 890-899 DOI: 10.1002/btpr.2096

Maiorano, F., L. Ambrosino and M. R. Guarracino (2015). The MetaboX Library: Building Metabolic Networks from KEGG Database. Bioinformatics and Biomedical Engineering: Third International Conference, IWBBIO 2015, Granada, Spain, April 15-17, 2015, Proceedings, Part I. F. Ortuño and I. Rojas. Cham, Springer International Publishing: 565-576 DOI: 10.1007/978-3-319-16483-0_55

De Santi, C., P. Tedesco, L. Ambrosino, B. Altermark, N. P. Willassen and D. de Pascale (2014). "A New Alkaliphilic Cold-Active Esterase from the Psychrophilic Marine Bacterium Rhodococcus sp.: Functional and Structural Studies and Biotechnological Potential." Appl Biochem Biotechnol. DOI: 10.1007/s12010-013-0713-1

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