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Terzibasi TozziniResearcher
Biology and Evolution of Marine Organisms Department

Tel.: +39 081 5833322
e-mail: eva.terzibasi(at)szn.it
Contatto Skype: eva terzibasi tozzini
Google scholar: https://scholar.google.com/citations?user=cpkslV4AAAAJ&hl=en

Curriculum Vitae


Research Interests

I graduated in marine biology and specialized during my PhD and postdoc in the Neurobiology of a very short-lived aquatic vertebrate model focusing on neurodegeneration, adult neuronal stem cells, adult neurogenesis and circadian rhythms. Neural adaptation of marine vertebrate to the different environments and environmental changes is a topic that is only sparsely studied. I am interested to investigate the neurobiology of marine organisms in an evolutionary and eco-physiological perspective, and in particular: 1. Comparative studies of CNS organization in different marine vertebrate species with basal position in the phylogenetic tree of chordates, with particular attention to brain neuroanatomy, neurogenetic niches distribution and neurotrophins - 2. Study of the visual system, with a special focus to the adaptations in extreme environments/habitats (differences between diurnal and nocturnal species, abyssal species, demersal pleuronectiformes) - 3. Study of the effect of  different types of (climatic/anthropic) environmental modifications - such as microplastic pollution, water acidification - on the CNS and the enteric nervous system (ENS) of some marine species of commercial interest (Dicentrarchus labrax). Due to the important functional role of the CNS in the adaptive response of an organism to its specific environment, a deeper comprehension of the active neural processes, such adult neurogenesis and neurodegeneration, could be a key factor for a more effective monitoring of the organisms health and the general balance of the ecosystem itself.

Selected Publications

Di Cicco E, Tozzini ET, Rossi G, Cellerino A. (2011). The short-lived annual fish Nothobranchius furzeri shows a typical teleost aging process reinforced by high incidence of age-dependent neoplasias. Exp Gerontol. 46(4):249-56. doi: 10.1016/j.exger.2010.10.011. Citato da Cell Previews

Tozzini ET, Baumgart M, Battistoni G, Cellerino A. (2012). Adult neurogenesis in the short-lived teleost Nothobranchius furzeri: localization of neurogenic niches, molecular characterization and effects of aging. Aging Cell. 11(2):241-51. doi: 10.1111/j.1474-9726.2011.00781.x. Commentato da Faculty of 1000

D'Angelo L, de Girolamo P, Lucini C, Terzibasi ET, Baumgart M, Castaldo L, Cellerino A. (2013) Brain derived neurotrophic factor: mRNA expression and protein distribution in the brain of the teleost Nothobranchius furzeri. J Comp Neurol. doi: 10.1002/cne.23457.

Tozzini ET, Dorn A, Ng'oma E, Polačik M, Blažek R, Reichwald K, Petzold A, Watters B, Reichard M, Cellerino A. (2013). Parallel evolution of senescence in annual fishes in response to extrinsic mortality. BMC Evol Biol. 3;13:77. doi: 10.1186/1471-2148-13-77.

Terzibasi Tozzini E, Savino A, Ripa R, Battistoni G, Baumgart M, Cellerino A. (2014). Regulation of microRNA expression in the neuronal stem cell niches during aging of the short-lived annual fish Nothobranchius furzeri. Front Cell Neurosci. 21;8:51. doi: 10.3389/fncel.2014.00051.

Baumgart M, Groth M, Priebe S, Savino A, Testa G, Dix A, Ripa R, Spallotta F, Gaetano C, Ori M, Terzibasi Tozzini E, Guthke R, Platzer M, Cellerino A. (2014). RNA-seq of the aging brain in the short-lived fish N. furzeri - conserved pathways and novel genes associated with neurogenesis. Aging Cell. 13(6):965-74. doi: 10.1111/acel.12257.

Baumgart M, Di Cicco E, Rossi G, Cellerino A, Tozzini ET. (2015)Comparison of captive lifespan, age-associated liver neoplasias and age-dependent gene expression between two annual fish species: Nothobranchius furzeri and Nothobranchius korthause. Biogerontology. 16(1):63-9. doi: 10.1007/s10522-014-9535-y. Commentato da Faculty of 1000

Blažek R, Polačik M, Kačer P, Cellerino A, Řežucha R, Methling C, Tomášek O, Syslová K, Terzibasi Tozzini E, Albrecht T, Vrtílek M, Reichard M. (2016). Repeated intraspecific divergence in life span and aging of African annual fishes along an aridity gradient. Evolution 71 (2), 386-402. Doi: 10.1111/evo.13127

Ripa R, Dolfi L, Terrigno M, Pandolfini L, Savino A, Arcucci V, Groth M, Terzibasi Tozzini E, Baumgart M, Cellerino A. (2017 MicroRNA miR-29 controls a compensatory response to limit neuronal iron accumulation during adult life and aging. BMC Biol. 13;15(1):9. doi: 10.1186/s12915-017-0354-x. Citato da Nature News

Terzibasi-Tozzini E1, Martinez-Nicolas A, Lucas-Sánchez A. (2017). The clock is ticking. Ageing of the circadian system: from physiology to cell cycle. Semin Cell Dev Biol. pii: S1084-9521(16)30309-3. doi: 10.1016/j.semcdb.2017.06.011.

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