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AmbrosinoPost Doc
RIMAR Department

e-mail: luca.ambrosino(at)szn.it
Tel. +39 081 5833452

Curriculum Vitae

 

Research Interests

My current research interests are focused on the development of bioinformatics methodologies and web accessible resources for structural and functional genomics, comparative genomics and molecular evolution of marine species.
During the PhD in “Computational Biology and Bioinformatics” at the University of Naples “Federico II”, I developed a pipeline for the prediction of ortholog, paralog and species-specific genes when comparing two species, based on sequence analyses at nucleotide and protein level, with subsequent construction of networks of orthologs and paralogs. The pipeline also includes the characterization of the networks through the prediction of functional domains, the involved enzymatic classes and the analysis of metabolic pathways.
I have also experience in three-dimensional modelling of protein structures and molecular dynamics simulation.
Here at the Stazione Zoologica “Anton Dohrn” I am mainly working on the development of the genomics section of the BIOINforMAtics service (see http://bioinfo.szn.it/), providing researchers with comparative genomics tools for the analysis and comparison of different species, and on the development of tools and services in the field of bioinformatics for research in SZN.

Selected Publications

Ambrosino, L., Colantuono, C., Monticolo, F., and Chiusano, M. L. (2017). “Bioinformatics resources for plant genomics: bottlenecks and opportunities in the -omics era.” in “Next-generation Sequencing and Bioinformatics for Plant Science” Current Issues in Molecular Biology 71-88 DOI: 10.21775/9781910190654.05

Ambrosino, L., Chiusano, M.L. (2017). “Transcriptologs: a transcriptome-based approach to predict orthology relationships.” Bioinformatics and Biology Insights 11 DOI: 10.1177/1177932217690136

Ambrosino, L., Bostan, H., Ruggieri, V., and Chiusano, M. L. (2016). “Bioinformatics resources for pollen.” Plant reproduction 29 (1-2), 133-147 DOI: 10.1007/s00497-016-0284-8

De Santi, C., B. Altermark, M. M. Pierechod, L. Ambrosino, D. de Pascale and N. P. Willassen (2016). "Characterization of a cold-active and salt tolerant esterase identified by functional screening of Arctic metagenomic libraries." BMC Biochem 17(1): 1 DOI: 10.1186/s12858-016-0057-x

Ambrosino, L., H. Bostan, P. di Salle, M. Sangiovanni, A. Vigilante and M. L. Chiusano (2016). "pATsi: Paralogs and Singleton Genes from Arabidopsis thaliana." Evol Bioinform Online 12: 1-7 DOI: 10.4137/EBO.S32536

De Santi, C., L. Ambrosino, P. Tedesco, L. Zhai, C. Zhou, Y. Xue, Y. Ma and D. de Pascale (2015). "Identification and characterization of a novel salt-tolerant esterase from a Tibetan glacier metagenomic library." Biotechnol Prog 31(4): 890-899 DOI: 10.1002/btpr.2096

Maiorano, F., L. Ambrosino and M. R. Guarracino (2015). The MetaboX Library: Building Metabolic Networks from KEGG Database. Bioinformatics and Biomedical Engineering: Third International Conference, IWBBIO 2015, Granada, Spain, April 15-17, 2015, Proceedings, Part I. F. Ortuño and I. Rojas. Cham, Springer International Publishing: 565-576 DOI: 10.1007/978-3-319-16483-0_55

De Santi, C., P. Tedesco, L. Ambrosino, B. Altermark, N. P. Willassen and D. de Pascale (2014). "A New Alkaliphilic Cold-Active Esterase from the Psychrophilic Marine Bacterium Rhodococcus sp.: Functional and Structural Studies and Biotechnological Potential." Appl Biochem Biotechnol. DOI: 10.1007/s12010-013-0713-1

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