You are here: HomeStaffList of PersonnelImperadore Pamela

ImperadorePost Doc
Biology and Evolution of Marine Organisms Department

Tel.: +39 081 5833281
Fax: +39 081 7641355
E-mail: pamela.imperadore(at)szn.it
Skype: pamela.imperadore

Curriculum Vitae

Supervisor: Graziano Fiorito
Appointed on project: Identification and localization of nociceptors and receptors in the arms and suckers of the cephalopod mollusc Octopus vulgaris

Research interests

Nociception is the neural process which allows encoding and processing of noxious stimuli induced by - for example - intense thermal, mechanical, or chemical stimuli. Such noxious events are detected by a subpopulation of specialized peripheral sensory neurons and fibres: i.e. the nociceptors. The presence of: i. nociceptors in the periphery and ii. pathways connecting the nociceptive system to higher brain centres, are considered two necessary criteria for the capacity to experience pain in animals.
Although cephalopods have been included in the Directive 2010/63/EU for the protection of animals used for scientific purposes as sole representative among invertebrates for their capacity to experience pain, suffering, distress and lasting harm, there is no published evidence for the identification and localization of nociceptors, including their pathways, in any cephalopod species. The primary aim of my project is to contribute to the knowledge on the presence of putative nociceptors and nociceptive pathways in the arm and sucker of the cephalopod mollusk Octopus vulgaris.
In order to achieve this goal, I will apply a combination of methods (i.e. in silico analysis, real-time qPCR, in situ hybridization and immunohistochemistry) to identify candidate nociceptors and eventually use markers to detect sensory fibers connecting periphery to brain.


Imperadore P, Fiorito G. (2018). Cephalopod Tissue Regeneration: consolidating over a century of knowledge. Frontiers in Physiology, 9: 593.

Imperadore P, Uckermann O, Galli R, Steiner G, Kirsch M, Fiorito G. (2018). Nerve regeneration in the cephalopod mollusc Octopus vulgaris: label-free multiphoton microscopy as a tool for investigation. Journal of the Royal Society Interface, 15: e 20170889.

Imperadore P, Shah SB, Makarenkova HP, Fiorito G. (2017). Nerve degeneration and regeneration in the cephalopod mollusc Octopus vulgaris: the case of the pallial nerve. Scientific Reports, 7 e 46564

Zullo L, Fossati SM, Imperadore P, Nödl MT. (2017). Molecular determinants of Cephalopod muscles and their implication in muscle regeneration. Frontiers in Cell and Developmental Biology, 5.

Lopes VM, Sampaio E, Roumbedakis K, Tanaka NK, Carulla L, Gambús G, Woo T, Martins CPP, Penicaud V, Gibbings C, Eberle J, Tedesco P, Fernández I, Rodríguez-González T, Imperadore P, Ponte G, Fiorito G. (2017). Cephalopod biology and care, a COST FA1301 (CephsInAction) training school: anaesthesia and scientific procedures. Invertebrate Neuroscience, 17: 8.


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