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daniello salvatoreResearcher
Section BEOM

Tel. +39 081 5833418
Fax: +39 081 7641355
e-mail salvatore.daniello(at)szn.it
Skype: salvatoredaniello


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Research interests

The D’Aniello group is interested in the evolution of metazoan genome’s architecture and the acquisition of genomic and functional innovations that allowed the enormous increase of the Nervous System complexity. The main research field is the Evolutionary and Development Biology (EvoDevo), and we use embryos from several animal models available in the lab, such as the amphioxus (Branchiostoma lanceolatum), the ascidian (Ciona intestinalis), the sea urchin (Strongylocentrotus purpuratus), and the zebrafish (Danio rerio).

Current projects focus on:
1. The characterization of the SoxB2 enhancer previously found to be exceptionally conserved from cnidarian to human. We use transgenic and knock-down approaches to study SoxB2 enhancer activity during Nervous System differentiation in ascidian and sea urchin embryos.

2. The investigation of the duplicated Nitric Oxide Synthase (NOS) genes during amphioxus development, trying to find out the primary NOS roles that are evolutionary conserved in chordates and novel functions acquired de novo in the vertebrate lineage. The Nitric Oxide is a unique signalling molecule involved in many physiological and developmental processes in all metazoans.

3. The identification of non-coding RNAs (ncRNA), a new class of regulatory molecules involved in several biological processes, including development and physiology of the Nervous System, involved in the Neurotrophins (NT) pathway. NTs are growth factors that control development, differentiation, synaptic plasticity and survival of neurons. We use the CRISPR/Cas9 methodology to produce knock-out NT zebrafish lines to acquire new insights on the genetic regulatory networks and functions exerted by NT during the development of Nervous System.

Journal Papers

Anishchenko E and D’Aniello S. Tunicate neurogenesis: the case of the SoxB2 missing CNE. Bringing Math to Life. Springer (in press 2015).

Vassalli QA, Anishchenko E, Caputi L, Sordino P, D'Aniello S* and Locascio A*. Regulatory elements retained during chordate evolution: Coming across tunicates. Genesis (2015) 53: 66-81.

Pascual-Anaya J, D’Aniello S, Kuratani S, Garcia-Fernàndez J. Evolution of the Hox clusters in deuterostomes. BMC Developmental Biology (2013) 13: 26.

Pascual-Anaya J, Adachi N, Alvarez S, Kuratani N, D’Aniello S*, Garcia-Fernàndez J*. Broken colinearity of amphioxus Hox cluster. EvoDevo (2012) 3: 28.

López-Doménech G, Serrat R, Mirra S, D’Aniello S, Somorjai I, Abad A, Vitureira N, García-Arumí E, Alonso MT, Rodriguez-Prados M, Burgaya F, Andreu AL, García-Sancho J, Trullas R, García-Fernàndez J and Soriano E. The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interacts with Miro and Trak2. Nature Communications (2012) 3:814.

Royo JL, Maeso I, Irimia M, Gao F, Peter IS, Lopes C, D’Aniello S, Casares F, Davidson EH, Garcia-Fernández J and Gómez-Skarmeta JL. Transphyletic conservation of developmental regulatory state in animal evolution. PNAS (2011) 108: 14186-91.

Andreakis N, D’Aniello S, Albalat R, Patti FP, Garcia-Fernàndez J, Procaccini G, Sordino P and Palumbo A. Evolution of the Nitric Oxide Synthase family in metazoans. Molecular Biology and Evolution (2011) 28:163-79.

Garcia-Fernàndez J, Jiménez-Delgado S, Pascual-Anaya J, Maeso I, Irimia M, Minguillón C, Benito-Gutiérrez E, Gardenyes J, Bertrand S and D’Aniello S. From the American to the European Amphioxus: towards Experimental Evo-Devo at the Origin of Chordates. International Journal of Developmental Biology (2009) 53: 1359-66.

Pascual-Anaya J, D’Aniello S and Garcia-Fernandez J. Unexpectedly large number of conserved non-coding regions within the ancestral chordate Hox cluster. Development, Genes and Evolution (2008) 218: 591-7.

D’Aniello S, Irimia M, Maeso I, Jiménez-Delgado S, Pascual-Anaya J, Bertrand S & Garcia-Fernàndez J. Gene expansion and retention leads to a diverse Tyrosine kinase superfamily in amphioxus. Molecular Biology and Evolution (2008) 25:1841-54.

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