You are here: HomeStaffList of PersonnelArnone Maria I.Arnone Maria I.

ina arnone c1139Research Director
Head Biology and Evolution of Marine Organisms Department

Tel. +39 081 5833203 - +39 081 5833255
Fax: +39 081 7641355
e-mail: ina.rnone(at)szn.it
Skype: miarnone

Curriculum Vitae

Organismi modello

Partner of the Marie Skłodowska-Curie Innovative Training Network EvoCELL

Research interests

The Arnone group aims at studying evolution of organs and body parts by comparison of the Gene Regulatory Networks (GRN) that control the formation and development of such parts in different animals using the sea urchin Strongylocentrotus purpuratus as main model system. An important aspect of this model is the phylogenetic position of this group in the animal kingdom. Sea urchins are echinoderms. Echinoderms, together with the sister group hemichordates, are ancient lineages of living non-chordates deuterostomes. Therefore, they provide an invaluable outgroup for assessment of what is ancient in chordates, what is chordate-specific, what is protostome-specific and represent a key group for studying the origin of deuterostomes. Two other deuterostome models were recently included in our studies: an other echinoderm, the sea star Patiria miniata and a hemichordate, the acorn worm Ptychodera flava, thus enabling for comparative analyses (EvoDevo) and evolution of GRNs studies.
Current projects focus on the following questions:
1. How to make a functional digestive tube? Echinoderms offer an ideal system to study the different factors involved in the morphogenesis of the gut and evolution of organogenesis. We are using comparative GRN approaches to study stomach, intestine, pancreas and muscle evolution.  
2. What sea urchins see? How do larvae and adults of sea urchins, despite the lack of a central nervous system and obvious eye-like structures, sense and respond to environmental light? Using a multidisciplinary approach, we are studying the morphological structure, molecular composition and physiological properties of photoreceptor cells in sea urchin larvae and adults.

Microinjection in sea urchin zygotes

Selected Publications

Lowe EK, Cuomo C, Arnone MI. Omics approaches to study gene regulatory networks for development in echinoderms. Briefings in Functional Genomics (2017) 16, 299-308.

Burguera D, Marquez Y, Racioppi C, Permanyer J, Torres-Méndez A, Esposito R, Albuixech-Crespo B, Fanlo L, D'Agostino Y, Gohr A, Navas-Perez E, Riesgo A, Cuomo C, Benvenuto G, Christiaen LA, Martí E, D'Aniello S, Spagnuolo A, Ristoratore F, Arnone MI*, Garcia-Fernàndez J*, Irimia M*. Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes. Nat Commun. (2017) 8: 1799.

Maria I. Arnone, Andrikou C, Annunziata R. Echinoderm systems for gene regulatory studies in evolution and development. Curr Opin Genet Dev (2016) 39, 129-137.

Perillo M, Wang YJ, Leach SD, and Maria I. Arnone. A pancreatic exocrine-like cell regulatory circuit operating in the upper stomach of the sea urchin Strongylocentrotus purpuratus larva. BMC Evol Biol (2016) 16, 117.

Rizzo F, Coffman JA, and Maria I. Arnone. An Elk transcription factor is required for Runx-dependent survival signaling in the sea urchin embryo. Dev Biol (2016) 416: 173-86.

Mao CA, Agca C, Mocko-Strand JA, Wang J, Ullrich-Lüter E, Pan P, Wang SW, Maria I. Arnone, Frishman LJ, Klein WH. Substituting mouse transcription factor Pou4f2 with a sea urchin orthologue restores retinal ganglion cell development. Proc. R. Soc. B (2016) 283 (1826), 20152978.

Andrikou C, Pai CY, Su YH, and Maria I. Arnone. Logics and properties of a genetic regulatory program that drives embryonic muscle development in an echinoderm. Elife (2015) 4, e07343.

Annunziata M and Maria I. Arnone. A dynamic network of regulatory interactions explains ParaHox gene control of gut patterning in the sea urchin embryo. Development (2014) 141: 2462-72.

Andrikou C, Iovene E, Rizzo F, Oliveri P and Maria I. Arnone. Myogenesis in the sea urchin embryo: the molecular fingerprint of the myoblast precursors. EvoDevo (2013) 4:33.

Annunziata R, Martinez P and Maria I. Arnone. Intact cluster and chordate-like expression of ParaHox genes in a sea star. BMC Biology (2013) 11:68.

Ullrich-Lüter E, Dupont S, Arboleda E, Hausen H and Maria I. Arnone. A Unique System of Photoreceptors in Sea Urchin Tube Feet. Proc Natl Acad Sci U S A (2011) 108: 8367-72.

Cole, AG, Rizzo F, Fernandez-Serra M, Martinez P, and Maria I. Arnone. ParaHox genes coordinate to pattern the posterior endoderm. Development (2009) 136: 541-9.

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