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FerraroResearcher
Department of Biology and Evolution of Marine Organisms

Tel.: +39 081 5833301
E-mail: francesco.ferraro(at)szn.it

Curriculum Vitae

 

 

 

 

Research Interests

The endomembrane system, already present in the LECA (Last Eukaryotic Common Ancestor), plays several roles in the biology of nucleated cell. This network of organelles in communication with each other is responsible for nutrient uptake, recycling or degradation of biopolymers, detection and relay of intra- and extracellular signals, synthesis and transport of enzymes, structural proteins and bioactive molecules (e.g., hormones) to their proper cellular location. It is, therefore, not surprising that 36% of human genes encode proteins that associate with this membrane-bound organelle network. Invertebrate Deuterostomes represent an appealing class of experimental models for two main reasons. Evolutionarily, they are close relatives of Vertebrates, sharing with them developmental stages and molecular mechanisms. However, contrary to Vertebrates, these organisms have non-duplicated genomes: an advantage for experimental manipulation and result interpretation.
My work focuses on the biosynthetic branch of the endomembrane system: the secretory pathway. For the reasons stated, the study of invertebrate Deuterostomes can provide valuable insight into specific structures and functions of the secretory pathway that are relevant to human physiology and pathology.

Research areas: protein biochemistry; cell biology; membrane traffic; organelle biosynthesis.

Selected Publications

Lopes-da-Silva M, McCormack JJ, Burden JJ, Harrison-Lavoie KJ, Ferraro F, Cutler DF. A GBF1-Dependent Mechanism for Environmentally Responsive Regulation of ER-Golgi Transport. Dev Cell. 2019 Jun 3;49(5):786-801.e6. doi: 10.1016/j.devcel.2019.04.006

Mencarelli C, Nitarska J, Kroecher T, Ferraro F, Massey K, Riccio A, Pichaud F. RanBP1 Couples Nuclear Export and Golgi Regulation through LKB1 to Promote Cortical Neuron Polarity. Cell Rep. 2018 Sep 4;24(10):2529-2539.e4. doi: 10.1016/j.celrep.2018.07.107.

McCormack JJ*, Lopes da Silva M*, Ferraro F*, Patella F*, Cutler DF. Weibel-Palade bodies at a glance. J Cell Sci. 2017 Nov 1;130(21):3611-3617. doi: 10.1242/jcs.208033
* Equal contribution

Ferraro F*, Mafalda Lopes da S, Grimes W, Lee HK, Ketteler R, Kriston-Vizi J, Cutler DF*. Weibel-Palade body size modulates the adhesive activity of its von Willebrand Factor cargo in cultured endothelial cells. Sci Rep. 2016 Aug 31;6:32473. doi: 10.1038/srep32473. * Corresponding author

Banushi B, Forneris F, Straatman-Iwanowska A, Strange A, Lyne AM, Rogerson C, Burden JJ, Heywood WE, Hanley J, Doykov I, Straatman KR, Smith H, Bem D, Kriston-Vizi J, Ariceta G, Risteli M, Wang C, Ardill RE, Zaniew M, Latka-Grot J, Waddington SN, Howe SJ, Ferraro F, Gjinovci A, Lawrence S, Marsh M, Girolami M, Bozec L, Mills K, Gissen P. Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis. Nat Commun. 2016 Jul 20;7:12111. doi: 10.1038/ncomms12111.

Ferraro F, Kriston-Vizi J, Metcalf DJ, Martin-Martin B, Freeman J, Burden JJ, Westmoreland D, Dyer CE, Knight AE, Ketteler R, Cutler DF. A two-tier Golgi-based control of organelle size underpins the functional plasticity of endothelial cells. Dev Cell. 2014 May 12;29(3):292-304. doi: 10.1016/j.devcel.2014.03.021.

Gauthier DJ, Sobota JA, Ferraro F, Mains RE, Lazure C. Flow cytometry-assisted purification and proteomic analysis of the corticotropes dense-core secretory granules. Proteomics. 2008 Sep;8(18):3848-61. doi: 10.1002/pmic.200700969.

Ferraro F, Ma XM, Sobota JA, Eipper BA, Mains RE. Kalirin/Trio Rho guanine nucleotide exchange factors regulate a novel step in secretory granule maturation. Mol Biol Cell. 2007 Dec;18(12):4813-25. doi: 10.1091/mbc.e07-05-0503

Sobota JA, Ferraro F, Bäck N, Eipper BA, Mains RE. Not all secretory granules are created equal: Partitioning of soluble content proteins. Mol Biol Cell. 2006 Dec;17(12):5038-52. doi: 10.1091/mbc.e06-07-0626

Ferraro F, Eipper BA, Mains RE. Retrieval and reuse of pituitary secretory granule proteins. J Biol Chem. 2005 Jul 8;280(27):25424-35. doi: 10.1074/jbc.M414156200

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