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Section BEOM

Tel. +39 081 5833407 - +39 081 5833416
Fax: +39 081 7641355
e-mail filip.vasilef(at)szn.it

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Research interests

The ultrastructure of the egg cortex in echinoderms varies with the species, but it is usually enriched with electron-lucent vesicles. In our previous study (Vasilev et al 2012, PLoS ONE), we found that these acidic vesicles appearing ‘white’ in the transmission electron microscopy either merge with one another or get exocytosed in starfish and sea urchin eggs at the time of fertilization or ionomycin-induced egg activation. The aim of my project is to clarify the role of the acidic vesicles in the generation of the Ca2+ signal in the egg cortex (cortical flash, CF), which has been known to represent the voltage-gated Ca2+ influx.

Journal Papers

Chun JT, Limatola N, Vasilev F, Santella L. (2014). Early events of fertilization in sea urchin eggs are sensitive to actin-binding organic molecules. Biochem. Biophys. Res. Commun., 450:1166-74.

Chun JT, Vasilev F, Santella L. (2013). Antibody against the actin-binding protein depactin attenuates Ca2+ signaling in starfish eggs. Biochem. Biophys. Res. Commun., 441(2):301-7.

Santella L, Vasilev F, Chun JT. (2012). Fertilization in echinoderms. Biochem. Biophys. Res. Commun., 425(3):588-94.

Vasilev F, Chun JT, Gragnaniello G, Garante E, Santella L. (2012). Effects of ionomycin on egg activation and early development in starfish. PLoS One. 7(6):e39231.

Chun JT, Puppo A, Vasilev F, Gragnaniello G, Garante E, Santella L. (2010). The biphasic increase of PIP2 in the fertilized eggs of starfish: new roles in actin polymerization and Ca2+ signaling. PLoS One. 5(11):e14100.

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