EMI
EMI
You are here: HomeStaffList of PersonnelSordino PaoloSordino Paolo

sordino paoloSenior Scientist
Biology and Evolution of Marine Organisms Department

Tel. +39 081 5833283 - +39 081 5833277
Fax: +39 081 7641355
e-mail paolo.sordino(at)szn.it
Skype: paolosordino

Curriculum Vitae

Research Interests

Our area of interest is the evolution and development of the central nervous system in the real world. The interplay between the development and ecology can generate genotypic and phenotypic variation within species, and these new combinations can be fixed by natural selection. We still know relatively little about the specific DNA sequences that underlie interesting changes of neuronal differentiation and function. By understanding the adaptive potential of the developing nervous system we aim to understand both proximate and external factors that regulate differential gene expression. We are particularly interested in the effect of natural and human-driven stimuli on embryonic processes at different levels of biological organization. Tunicates and fishes are placed at the phylogenetic transition between invertebrates and vertebrates, and important anatomical and functional innovations occurred during this key step in the evolutionary history of the nervous system. Each of these systems offers different advantages. Research projects address specific neurogenic factors and processes, i.e. neuromodulators (endocannabinoids and visual system), neurotransmitters (metal ions and catecholaminergic neurons), neuroinflammation (seizures and subpallial circuits), and sensory organ variation (naturally occurring mutations). We use molecular genetic, systematic and developmental techniques to address these problems, and our lab incorporates field studies and a behavioural facility to explore environmental responses in Ciona intestinalis and zebrafish. Understanding environment-development interactions in this integrated way provides us with ideas on genetic differences that underlie evolutionary traits, and tools for health risk assessment and drug discovery.

Selected Publications

Valero-Gracia A, Marino R, Crocetta F, Nittoli V, Tiozzo S, Sordino P, 2016. Comparative localization of serotonin-like immunoreactive cells in Thaliacea informs tunicate phylogeny. Front Zool, 13: 45.

Martella A, Sepe RM, Silvestri C, Zang J, Fasano G, Carnevali O, De Girolamo P, Neuhauss SCF, Di Marzo V, Sordino P, 2016. Important role of endocannabinoid signaling in the development of functional vision and locomotion in zebrafish. FASEB J, 30: 4275-4288.

Pappalardo A, Porreca I, Caputi L, De Felice E, Schulte-Merker S, Zannini M, Sordino P, 2015. Thyroid development in zebrafish lacking TAZ. Mech Dev, 138: 268-278.

Affinito O, Andreakis N, Caputi L, Marino R, Pannone R, Sordino P, Procaccini G, 2015. High connectivity and directional gene flow in European Atlantic and Mediterranean populations of Ciona intestinalis sp. A. Mar Ecol: Evol Persp, 36: 1230-1243.

De Felice E, Porreca I, Alleva E, De Girolamo P, Ciriaco E, Germanà A, Sordino P, 2014. Localization of BDNF expression in the developing brain of zebrafish. J Anat, 224: 564-574.

Cima F, Caicci F, Sordino P, 2014. The haemocytes of the salp Thalia democratica (Tunicata, Thaliacea): an ultrastructural and histochemical study in the oozoid. Acta Zool, 95: 375-391.

Ferriero R, Manco G, Lamantea E, Nusco E, Ferrante MI, Sordino P, Stacpoole PW, Lee B, Zeviani M, Brunetti-Pierri N, 2013. Phenylbutyrate therapy for pyruvate dehydrogenase complex deficiency and lactic acidosis. Science Transl Med, 5 (175): 175ra31.

Porreca I, De Felice E, Fagman H, Di Lauro R, Sordino P, 2012. Zebrafish bcl2l is a survival factor in thyroid development. Dev Biol, 366: 142-152.

Del Giacco L, Pistocchi A, Cotelli F, Fortunato AE, Sordino P, 2008. A peek inside the neurosecretory brain through Orthopedia lenses. Dev Dyn 237: 2295-2303.

Caputi L, Andreakis N, Mastrototaro F, Cirino P, Vassillo M, Sordino P, 2007. Cryptic speciation in a model invertebrate chordate. Proc Natl Acad Sci USA, 104: 9364-9369.

Book chapters

Procaccini G, Affinito O, Toscano F, Sordino P, 2011. A new animal model for merging ecology and evolution. In: Evolutionary Biology – Concepts, Biodiversity, Macroevolution and Genome Evolution, Springer. Part 2: 91-106.

 

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