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ianora adriannaDirector of Research
Integrative Marine Ecology Department

Tel. +39 081 5833246
Fax: +39 081 7641355
e-mail: adrianna.ianora(at)szn.it
Skype: adriannaianora

Curriculum Vitae

Research interests

In nature, chemistry‐based interactions often regulate growth and survival of micro‐ and macro‐organisms, thus determining biological success and shaping community processes such as seasonal succession, niche structure and population dynamics. What make these chemicals of human and commercial interest is related to their bioactivity and their potential application as pharmaceuticals for the treatment of numerous diseases. My research uses ecological insights on plant-animal interactions in the plankton to increase rates of discovery of possible medicines from marine microalgae. For example, we were the first to discover that diatoms produce anti-proliferative compounds (polyunsaturated aldehydes) that potentially sabotage future generations of copepods by inducing abortions, birth defects and slow development rates. These metabolites also activate extrinsic apoptotic cell death in lung and colon adenocarcinoma cell lines without affecting the viability of normal cells from the same tissue type, indicating possible biotechnological applications of such compounds. Currently I am exploring the biotechnological applications of microalgal secondary metabolites as pharmaceuticals and am involved in starting a research-based spin off company (BioSEArch s.r.l.) searching for innovative drugs with anticancer, anti-inflammatory and anti-infective activities. https://www.biosearchsrl.com/.

Selected Publications

Miralto A, Barone G, Romano G, Poulet SA, Ianora A, Russo L, Buttino I, Mazzarella G, Laabir M, Cabrini M, Giacobbe MG. 1999. The insidious effect of diatoms on copepod reproduction. Nature 402: 173-176.

Ianora A, Miralto A, Poulet SA, Carotenuto Y, Buttino I, Romano G, Casotti R, Pohnert G, Wichard T, Colucci D’Amato L, Terrazzano G, Smetacek V. 2004. Aldehyde suppression of copepod recruitment in blooms of a ubiquitous planktonic diatom. Nature 429: 403-407.

Carotenuto Y, Dattolo E, Lauritano C, Pisano F, Sanges R, Miralto A, Procaccini G, Ianora A. 2014. Insights into the transcriptome of the copepod Calanus helgolandicus feeding on the oxylipin-producing diatom Skeletonema marinoi. Harmful Algae 31: 153–162

Lettieri A, Esposito R, Spagnuolo A, Ianora A. 2015. Ciona intestinalis as a marine model system to better understand the toxic effects of diatom-derived aldehydes on gene targets during development. Mar. Drugs 13: 1451-1465

Jaspars M, de Pascale D, Andersen JH, Reyes F, Crawford AD, Ianora A. The marine biodiscovery pipeline and ocean medicines of tomorrow. 2016. J. Mar. Biol. Ass. UK 96: 151–158.

Di Dato V, Orefice I, Fontanarosa C, Moresano A, Ianora A, Romano G. 2017. Animal-like prostaglandins in marine microalgae. ISME Journal 11: 1722–1726 doi:10.1038/ismej.2017.27

Lauritano C, De Luca D, Ferrarini A, Avanzato C, Minio A, Esposito F, Ianora A. 2017. De novo transcriptome of the cosmopolitan dinoflagellate Amphidinium carterae to identify enzymes with biotechnological potential. Scientific Reports | 7: 11701 | DOI:10.1038/s41598-017-12092-1 1

Manzo E, Cutignano A, Pagano D, Gallo C, Barra G, Nuzzo G, Sansone C, Ianora A, Urbanek K, Fenoglio D, Ferrera F, Bernardi C, Parodi A, Pasquale G, Leonardi A, Filaci G, De Palma R, Fontana A. 2017. A new marine-derived sulfoglycolipid triggers dendritic cell activation and immune adjuvant response. Scientific Reports 7: 6286 | DOI:10.1038/s41598-017-05969-81

Sansone C, Galasso C, Orefice I, Nuzzo G, Luongo E, Cutignano A, Romano G, Brunet C, Fontana A, Esposito F, Ianora A.2017. The green microalga Tetraselmis suecica reduces oxidative stress and induces repairing mechanisms in human cells Scientific Reports 7:41215 | DOI: 10.1038/srep41215

Lauritano C, Martin J, de la Cruz M, Reyes F, Romano G, Ianora A. 2018. First identification of marine diatoms with anti-tuberculosis activity Scientific Reports 8:2284 | DOI:10.1038/s41598-018-20611-x.

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