EMI
EMI
You are here: HomeStaffList of PersonnelChun Jong TaiChun Jong Tai

chun jong taiTechnologist
Biology and Evolution of Marine Organisms Department

Tel. +39 081 5833407
Fax: +39 081 7641355
e-mail chun(at)szn.it


Curriculum Vitae


Research interests

Starfish oocytes and sea urchin eggs provide an optimal opportunity to study the cytological events of meiotic progression, fertilization, and cell division. The eggs passing through these stages manifest accelerated remodelling of the actin cytoskeleton and transitional changes of the intracellular calcium levels. In recent years, our research activities have mostly focused on the reciprocal influence of the intracellular calcium signals and the actin cytoskeleton, which was monitored by use of microinjected fluorescent probes for free calcium, actin filaments, and various exogenous proteins interfering with the normal regulation of the actin cytoskeleton. Our recent acquisition of the transcriptome information on the oocytes and early embryos of the local species of starfish (Astropecten aranciacus) is expected to expedite the development of diverse approaches to target the key elements involved in intracellular calcium signalling and the cytoskeletal controls.

Selected Publications

Musacchia F, Vasilev F, Borra M, Biffali E, Sanges R, Santella L, Chun JT. (2017) De novo assembly of a transcriptome from the eggs and early embryos of Astropecten aranciacus. PLoS One 12:e0184090.

Limatola N, Chun JT, Kyozuka K, Santella L (2015) Novel Ca2+ increases in the maturing oocytes of starfish during the germinal vesicle breakdown. Cell Calcium 58:500-510.

Santella L, Limatola N, Chun JT (2015) Calcium and actin in the saga of awakening oocytes. Biochem. Biophys. Res. Commun. 460:104-113.

Chun JT, Limatola N, Vasilev F, and Santella L (2014). Early events of fertilization in sea urchin eggs are sensitive to actin-binding organic molecules. Biochem. Biophys. Res. Commun. 450:1166-1174.

Chun JT, Vasilev F, and Santella L (2013) Antibody against the actin-binding protein depactin attenuates Ca2+ signaling in starfish eggs. Biochem. Biophys. Res. Commun. 441:301-307.

Santella L and Chun JT (2011). Actin, more than just a housekeeping protein at the scene of fertilization. Sci. China Life Sci. 54:733-743.

Chun JT, Puppo A, Gragnaniello G, Garante E, and Santella L (2010). The biphasic increase of PIP2 in the fertilized eggs of starfish: new roles for actin polymerization and Ca2+ signaling. PLoS ONE 5:e14100.

Chun JT and Santella L. (2009). The actin cytoskeleton in meiotic maturation and fertilization of starfish eggs. Biochem. Biophys. Res. Commun. 384:141-143.

Chun JT and Santella L (2009). Roles of the actin-binding proteins in intracellular Ca2+ signaling. Acta Physiologica 195:61-70.

Santella L, Puppo A, and Chun JT (2008). The role of the actin cytoskeleton in calcium signaling in starfish oocytes. Int. J. Dev. Biol. 52:571-584.

Kyozuka K, Chun JT, Puppo A, Gragnaniello G, Garante E, and Santella L (2008). Actin cytoskeleton modulates calcium signalling during the maturation of starfish oocytes. Dev. Biol. 320:426-435.

Puppo A, Chun JT, Gragnaniello G, Garante E, and Santella L (2008). Alteration of the cortical actin cytoskeleton deregulates Ca2+ signaling, monospermic fertilization, and sperm entry. PLoS ONE 3:e3588.

Book chapters

Chun JT, Vasilev F, Limatola N, Santella L (2018) Fertilization in Starfish and Sea Urchin: Roles of Actin. In: Kloc M and Kubiak JZ (eds.) Marine Organisms as Model Systems. Sereies Title: Results and Problems in Cell Differentiation, Springer Nature.

Santella L, Limatola N, and Chun JT (2014) Actin Cytoskeleton and Fertilization in Starfish Eggs. In: H. Sawada. (eds.) Sexual Reproduction in Animals and Plants, Springer Verlag, Japan, ISBN 978-4-43154588-0

Chun JT and Santella L. (2013) Intracellular Calcium Waves. In: Lennarz, W.J. and Lane, M.D. (eds.) The Encyclopedia of Biological Chemistry, Vol. 2, pp. 640-647. Academic Press, Waltham, MA, USA.

Santella L and Chun JT (2013) Calcium Signaling by Cyclic ADP-Ribose and NAADP. In: Lennarz, W.J. and Lane, M.D. (eds.) The Encyclopedia of Biological Chemistry, Vol. 1, pp. 331-336. Academic Press, Waltham, MA, USA.

Chun JT and Santella L (2007). Calcium and fertilization. In: “Calcium, A Matter of Life or Death”. (Ed. by J. Krebs and M. Michalak). pp.425-470, Elsevier B.V., Amsterdam, The Netherlands.

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