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castellano immacolataResearcher
Biology and Evolution of Marine Organisms Department

Tel. +39 081 5833293
Fax: +39 081 7641355
e-mail immacolata.castellano(at)szn.it

Curriculum Vitae

Research interests

Oceans are very dynamic environments and are characterized by changes of temperature, pH, salinity, and oxygen availability. Marine organisms have adapted to survive to changing environments through different physiological, molecular and chemical strategies. At the molecular level, they have evolved enzymes and/or metabolic pathways with unique properties to function “at the top” in different environmental niches. The knowledge of marine molecular biodiversity and of the fundamental biological processes underlying the ocean’s life can inspire scientists for innovative and eco-sustainable solutions to preserve our planet.
My research interests involve: 1. the study of the molecular mechanisms underpinning the response and adaptation of marine organisms to environmental constraints with major focus on redox-sensitive pathways; 2. the study of the structure, function and evolution of sulfoxide synthase involved in 5-thiohistidine biosynthesis in marine organisms; 3. the discovery of 5-thiohistidine biological activities.

Selected Publications

Castellano I*, Seebeck FP. (2018) “On ovothiol biosynthesis and biological roles: from life in the ocean to therapeutic potential” Nat Prod Rep. Natural Product Reports, 2018, 35, 1241 – 1250 doi: 10.1039/c8np00045j.

Brancaccio M, D’Argenio G, Lembo V, Palumbo A, Castellano I* (2018) "Anti-fibrotic effect of marine ovothiol in an in vivo model of liver fibrosis" Ox Med Cell Longev doi: 10.1155/2018/5045734.

Castellano I, Di Tomo P, Di Pietro N, Mandatori D, Pipino C, Formoso G, Napolitano A, Palumbo A, Pandolfi A. (2018) “Anti-inflammatory activity of marine ovothiol A in an in vitro model of endothelial dysfunction induced by hyperglycemia” Oxid Med Cell Longev doi: 10.1155/2018/2087373

Castellano I*, Migliaccio O, Ferraro G, Maffioli E, Marasco D, Merlino A, Zingone A, Tedeschi G, Palumbo A (2018) “Biotic and environmental stress induces nitration and changes in structure and function of the sea urchin major yolk protein toposome”. Sci. Rep. 8:4610. doi: 10.1038/s41598-018-22861-1.

Kumar A, Castellano I, Patti FP, Delledonne M, Abdelgawad H, Beemster GT, Asard H, Palumbo A, Buia MC (2017) “Molecular response of Sargassum vulgare to acidification at volcanic CO2 vents - insights from de novo transcriptomic analysis”. Mol Ecol. doi: 10.1111/mec.14034.

Kumar A, AbdElgawad H, Castellano I, Lorenti M, Delledonne M, Beemster GTS, Asard H, Buia MC, Palumbo A (2017) “Physiological and Biochemical Analyses Shed Light on the Response of Sargassum vulgare to Ocean Acidification at Different Time Scales” Front Plant Sci. 19; 8:570. doi: 10.3389/fpls.2017.00570.

Castellano I*, Migliaccio O, D’Aniello S, Merlino A, Napolitano A, Palumbo A (2016) “Shedding light on ovothiol biosynthesis in marine metazoans” Sci. Rep. 6:21506. doi: 10.1038/srep21506.

Migliaccio O, Castellano I, Di Cioccio D, Tedeschi G, Negri A, Cirino P, Romano G, Zingone A, Palumbo A (2016) “Subtle reproductive impairment through nitric oxide-mediated mechanisms in sea urchins from an area affected by harmful algal blooms” Sci. Rep. 6:26086. doi: 10.1038/srep26086.

Castellano I, Ercolesi E, Romano G, Ianora A, Palumbo A (2015) “The diatom-derived aldehyde decadienal affects life cycle transition in the ascidian Ciona intestinalis through nitric oxide/ERK signaling” Open Biol. 5(3):140182. doi: 10.1098/rsob.140182.

Castellano I, Ercolesi E, Palumbo A (2014) "Nitric Oxide Affects ERK Signaling through Down- regulation of MAP Kinase Phosphatase Levels during Larval Development of the Ascidian Ciona intestinalis" PloS One. 9(7):e102907. 10.1371/journal.pone.0102907.

Migliaccio O, Castellano I, Romano G, Palumbo A (2014) “Stress response to cadmium and manganese in Paracentrotus lividus developing embryos is mediated by nitric oxide”. Aquatic Toxicology. 156C:125-134. doi: 10.1016/j.aquatox.2014.08.007.

Russo GL, Russo M, Castellano I, Napolitano A, Palumbo A (2014) “Ovothiol Isolated from Sea Urchin Oocytes Induces Autophagy in Hep-G2 cell line” Mar. Drugs. 12, 4069-4085; doi:10.3390/md12074069.

Castellano I*, Merlino A (2012) “γ-Glutamyltranspeptidases: sequence, structure, biochemical properties, and biotechnological applications“, Cell Mol Life Sci. 69, 3381-94.

Castellano I*, Di Salle A, Merlino A, Rossi M, La Cara F (2011) “Gene cloning and protein expression of gamma-glutamyltranspeptidases from Thermus thermophilus and Deinococcus radiodurans: comparison of molecular and structural properties with mesophilic counterparts” Extremophiles 15, 259-270.

Castellano I*, Merlino A, Rossi M, La Cara F (2010) “Biochemical and structural properties of gamma-glutamyl transpeptidase from Geobacillus thermodenitrificans: an enzyme specialized in hydrolase activity”, Biochimie 92, 464-474.

Castellano I, Ruocco MR, Cecere F, Di Maro A, Chambery A, Michniewicz A, Parlato G, Masullo M, De Vendittis E, (2008) “Glutathionylation of the iron superoxide dismutase from the psychrophilic eubacterium Pseudoalteromonas haloplanktis”, Biochim Biophys Acta, 1784, 816-826.

Castellano I, Di Maro A, Ruocco MR, Chambery A, Parente A, Di Martino MT, Parlato G, Masullo M, De Vendittis E, (2006) “Psychrophilic superoxide dismutase from Pseudoalteromonas haloplanktis: biochemical characterization and identification of a highly reactive cysteine residue”, Biochimie 88, 1377-1389.


Castellano I and Merlino A, (2013) “Gamma-Glutamyl Transpeptidases”, SpringerBriefs in Biochemistry and Molecular Biology, DOI: 10.1007/978-3-0348-0682-4_1.

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